The Manning Lab

Research on Kinases, Genomics, Evolution and the grand mysteries of biology


News and Events

Dec 12 2016
We're looking for a postdoc to work on cancer mutation analysis, and have contract position open for a computational research associate.

Dec 3 2016
Phosphatome Updates
Mark and Gerard have made substantial updates to the Phosphatome website and wiki. Mark's phosphatome paper is under review at Science Signaling.

May 12, 2016
New Oncogenic Kinase Mutations
In a paper lead by the Malek lab at Genentech, we've helped show how deleting a loop in the kinase domain is an oncogenic mechanism in EGFR, HER2 and BRAF kinases.

Oct 25, 2014
Multiple functions of HSF1
Another collaboration with the Dillin lab, Ana Rodrigues Grant explored the function of a heat shock factor (HSF1) mutant that doesn't activate heat shock transcription but still protects from stress (Science).

About the Manning Lab


Gerard Manning's research group at the Salk Institute explored biology using genomics and bioinformatics. The lab housed the Razavi Newman Center for Bioinformatics which provided bioinformatics support to other researchers at the Salk Institute. Research areas included the genomics and evolution of protein kinases and phosphatases, the genomics of aging, neurodegeneration and proteostasis, and the development of new methods for gene finding and orthology prediction in eukaryotes.


The Razavi-Newman center was disbanded in 2012. Gerard and Mark moved to set up a new group at Genentech, and most other lab members remained in San Diego. In 2016, lab alum Galina Erikson was hired back to Salk to help run the new Integrative Genomics & Bioinformatics Core.

The Manning lab at Genentech will focus on integrated cancer genomics, looking to boil down large amounts of genomic data into the strategies used by cancer cells, in order to better undrestand them...and then kill them.