The Manning Lab
Research on Kinases, Genomics, Evolution and the grand mysteries of biology
News and Events
April 11, 2017
Phosphatome paper published
Mark's epic definition and analysis of the phosphatome, across 9 eukaryotic species, is now the cover article at Science Signaling.
Dec 12 2016
We're looking for a postdoc to work on cancer mutation analysis, and have contract position open for a computational research associate.
Sep 3 2016
Evolution of cell death
Using orthology techniques developed for kinome analysis, we've shown that the necroptosis pathway, including RIPK and MLKL kinases, is selectively lost in marsupials and some other mammals. See Annual Reviews paper by Newton & Manning.
May 12, 2016
New Oncogenic Kinase Mutations
In a paper lead by the Malek lab at Genentech, we've helped show how deleting a loop in the kinase domain is an oncogenic mechanism in EGFR, HER2 and BRAF kinases.
About the Manning Lab
Gerard Manning's research group at the Salk Institute explored biology using genomics and bioinformatics. The lab housed the Razavi Newman Center for Bioinformatics which provided bioinformatics support to other researchers at the Salk Institute. Research areas included the genomics and evolution of protein kinases and phosphatases, the genomics of aging, neurodegeneration and proteostasis, and the development of new methods for gene finding and orthology prediction in eukaryotes.
The Razavi-Newman center was disbanded in 2012. Gerard and Mark moved to set up a new group at Genentech, and most other lab members remained in San Diego. In 2016, lab alum Galina Erikson was hired back to Salk to help run the new Integrative Genomics & Bioinformatics Core.
The Manning lab at Genentech will focus on integrated cancer genomics, looking to boil down large amounts of genomic data into the strategies used by cancer cells, in order to better understand them...and then kill them.
This website will continue, both to provide information supporting our signaling work at Salk, as well as ongoing published research from Genentech.