The Manning Lab

Research on Kinases, Genomics, Evolution and the grand mysteries of biology


News and Events

Nov 26 2014
Kinase Evolution in Arthropods
As part of the centipede genome publication in PLoS Biology, Galina Erickson compared dozens of athropod kinomes and found extensive kinase loss across several arthropod lineages.

Oct 25, 2014
Multiple functions of HSF1
Another collaboration with the Dillin lab, Ana Rodrigues Grant explored the function of a heat shock factor (HSF1) mutant that doesn't activate heat shock transcription but still protects from stress (Science).

Aug 26 2012
Worm lifespan and the proteosome
We supported the Dillin lab in a Nature paper showing the role of a proteasome subunit in proteostasis and longevity in worms.

Aug 10 2012
New Golgi kinase builds bone
A collaboration with the Ken Irvine's lab lead to a publication on FAM20C, a novel human kinase that phosphorylates secreted bone proteins in the Golgi, and is likely the long-sought after 'casein kinase'.

May 13 2012
Plant Enzyme Evolution
Our Nature paper shows how CHI, a key enzyme in isoprenoid biosynthesis, evolved from a novel family of fatty acid-binding proteins.

May 1 2012
Ancient Origin of Tyrosine Kinases
In collaboration with the Ruiz-Trillo lab, our Science Signaling paper shows massive diversity of tyrosine kinases even before the emergence of choanoflagellates and metazoans.

April 5, 2012
Wiki update
New articles on Wikinome include exploration of the protein kinase activities of several lipid kinases, including the PIK and PIPK families, and a redefinition of the Atypical kinase group.

About the Manning Lab


Gerard Manning's research group at the Salk Institute explored biology using genomics and bioinformatics. The lab housed the Razavi Newman Center for Bioinformatics which provided bioinformatics support to other researchers at the Salk Institute. Research areas included the genomics and evolution of protein kinases and phosphatases, the genomics of aging, neurodegeneration and proteostasis, and the development of new methods for gene finding and orthology prediction in eukaryotes.


The Razavi-Neman center was disbanded in 2012. Gerard and Mark moved to set up a new group at Genentech, and most other lab members remained in San Diego.

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The Manning lab is moving! Gerard is moving to Genentech, in San Francisco, where he will be director of discovery bioinformatics. Mark is also moving to Genentech and we will rebuild the group there. All other current lab members are staying in San Diego. Current projects will be finishing up in 2012 and 2013. Kinase.Com will be maintained, and the new lab will continue a focus on kinase signaling and evolutionary bioinformatics.