News and Events
2022
Evolution of translational bypassing
Gerard collaborated with the John Atkins lab to use comparative genomics to better understand a strange case of ribosomes skipping a 50 nt region of mRNA (Full Text @ BioRxiv)
2020
Breast Cancer Genomics
Jacob Rinaldi's analysis of partial genomics of over 11,000 breast tumors has yielded insights into genomic subtyping and tumor evolution (Full Text @ PLoS One )
Aug 17, 2019
RIPK3 viral evolution paper
In collaboration with James Murphy's lab at WEHI, we explored evolution viral homologs of the RIPK3 kinase and how their sequence changes enable them to interfere with necroptosis. (Full Text @ Cell Reports)
Jan 31 2018
HER2 breast cancer
Anneleen Daemen's very nice genomic analysis of HER2-amplified breast cancer has been published, showing important differences between the genomic event and the subtype, and finding new evidence for an androgen-driven subtype. (Full Text)
April 11, 2017
Phosphatome paper published
Mark's epic definition and analysis of the phosphatome, across 9 eukaryotic species, is now the cover article at Science Signaling.
About the Manning Lab
Salk
Gerard Manning's research group at the Salk Institute explored biology using genomics and bioinformatics. The lab housed the Razavi Newman Center for Bioinformatics which provided bioinformatics support to other researchers at the Salk Institute. Research areas included the genomics and evolution of protein kinases and phosphatases, the genomics of aging, neurodegeneration and proteostasis, and the development of new methods for gene finding and orthology prediction in eukaryotes.
Genentech
The Razavi-Newman center was disbanded in 2012. Gerard and Mark moved to set up a new group at Genentech, and most other lab members remained in San Diego. In 2016, lab alum Galina Erikson was hired back to Salk to help run the new Integrative Genomics & Bioinformatics Core.
The Manning lab at Genentech focused on integrated cancer genomics, looking to boil down large amounts of genomic data into the strategies used by cancer cells, in order to better understand them...and then kill them. Recent publications are on the Publications tab.
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