Manning Lab Publications

2019

Viral MLKL homologs subvert necroptotic cell death by sequestering cellular RIPK3.
Petrie, EJ, Sandow, JJ, Liang, L-Y, Coursier, D, Young, SN, Kersten, WJA, Fitzgibbon, C, Lowes, KN, Au, AE, Sabroux, HJ, Lalaoui, N, Webb, AI, Lessene, G, Manning, G, Lucet, IS, Murphy, JM.
Cell Reports 28: 3309-19. PubMed, Full Text

2018

HER2 is not a cancer subtype but rather a pan-cancer driver and is highly enriched in molecular apocrine breast tumors.
Daemen, A, Manning, G.
Breast Cancer Research 20:8. PubMed, Full Text

2017

Genomics and Evolution of Protein Phosphatases.
Chen, MJ, Dixon, JE, Manning, G.
Sci. Signal. 10(474): eaag1796. PubMed, Full Text

2016

Necroptosis and Inflammation
Newton K, Manning G.
Annu Rev Biochem. 85:743-63. doi: 10.1146/annurev-biochem-060815-014830. PubMed, Full Text

Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2
Foster SA, Whalen DM, Özen A, Wongchenko MJ, Yin J, Yen I, Schaefer G, Mayfield JD, Chmielecki J, Stephens PJ, Albacker LA, Yan Y, Song K, Hatzivassiliou G, Eigenbrot C, Yu C, Shaw AS, Manning G, Skelton NJ, Hymowitz SG, Malek S.
Cancer Cell 29(4):477-93. doi: 10.1016/j.ccell.2016.02.010. PubMed

2015

Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors
Daemen A, Peterson D, Sahu N, McCord R, Du X, Liu B, Kowanetz K, Hong R, Moffat J, Gao M, Boudreau A, Mroue R, Corson L, O'Brien T, Qing J, Sampath D, Merchant M, Yauch R, Manning G, Settleman J, Hatzivassiliou G, Evangelista M.
Proc Natl Acad Sci U S A. 112(32):E4410-7. doi: 10.1073/pnas.1501605112. PubMed

Leveraging the Pre-DFG Residue Thr-406 To Obtain High Kinase Selectivity in an Aminopyrazole-Type PAK1 Inhibitor Series
Rudolph J, Aliagas I, Crawford JJ, Mathieu S, Lee W, Chao Q, Dong P, Rouge L, Wang W, Heise C, Murray LJ, La H, Liu Y, Manning G, Diederich F, Hoeflich KP.
ACS Med Chem Lett. 6(6):711-5. doi: 10.1021/acsmedchemlett.5b00151. PubMed

Key challenges for the creation and maintenance of specialist protein resources
Holliday GL, Bairoch A, Bagos PG, Chatonnet A, Craik DJ, Finn RD, Henrissat B, Landsman D, Manning G, Nagano N, O'Donovan C, Pruitt KD, Rawlings ND, Saier M, Sowdhamini R, Spedding M, Srinivasan N, Vriend G, Babbitt PC, Bateman A.
Proteins. 83(6):1005-13. doi: 10.1002/prot.24803. PubMed

A comprehensive transcriptional portrait of human cancer cell lines
Klijn C, Durinck S, Stawiski EW, Haverty PM, Jiang Z, Liu H, Degenhardt J, Mayba O, Gnad F, Liu J, Pau G, Reeder J, Cao Y, Mukhyala K, Selvaraj SK, Yu M, Zynda GJ, Brauer MJ, Wu TD, Gentleman RC, Manning G, Yauch RL, Bourgon R, Stokoe D, Modrusan Z, Neve RM, de Sauvage FJ, Settleman J, Seshagiri S, Zhang Z.
Nat Biotechnol. 33(3):306-12. doi: 10.1038/nbt.3080 PubMed

Bioinformatics analysis of thousands of TCGA tumors to determine the involvement of epigenetic regulators in human cancer
Gnad F, Doll S, Manning G, Arnott D, Zhang Z.
BMC Genomics. Suppl 8:S5. doi: 10.1186/1471-2164-16-S8-S5. PubMed

Creating a specialist protein resource network: a meeting report for the protein bioinformatics and community resources retreat
Babbitt PC, Bagos PG, Bairoch A, Bateman A, Chatonnet A, Chen MJ, Craik DJ, Finn RD, Gloriam D, Haft DH, Henrissat B, Holliday GL, Isberg V, Kaas Q, Landsman D, Lenfant N, Manning G, Nagano N, Srinivasan N, O'Donovan C, Pruitt KD, Sowdhamini R, Rawlings ND, Saier MH Jr, Sharman JL, Spedding M, Tsirigos KD, Vastermark A, Vriend G.
Database (Oxford). 2015:bav063. doi: 10.1093/database/bav063. PubMed

2014

The First Myriapod Genome Sequence Reveals Conservative Arthropod Gene Content and Genome Organisation in the Centipede Strigamia maritima
Chipman AD, Ferrier DE, Brena C, Qu J, Hughes DS, Schröder R, Torres-Oliva M, Znassi N, Jiang H, Almeida FC, Alonso CR, Apostolou Z, Aqrawi P, Arthur W, Barna JC, Blankenburg KP, Brites D, Capella-Gutiérrez S, Coyle M, Dearden PK, Du Pasquier L, Duncan EJ, Ebert D, Eibner C, Erikson G, Evans PD, Extavour CG, Francisco L, Gabaldón T, Gillis WJ, Goodwin-Horn EA, Green JE, Griffiths-Jones S, Grimmelikhuijzen CJ, Gubbala S, Guigó R, Han Y, Hauser F, Havlak P, Hayden L, Helbing S, Holder M, Hui JH, Hunn JP, Hunnekuhl VS, Jackson L, Javaid M, Jhangiani SN, Jiggins FM, Jones TE, Kaiser TS, Kalra D, Kenny NJ, Korchina V, Kovar CL, Kraus FB, Lapraz F, Lee SL, Lv J, Mandapat C, Manning G, Mariotti M, Mata R, Mathew T, Neumann T, Newsham I, Ngo DN, Ninova M, Okwuonu G, Ongeri F, Palmer WJ, Patil S, Patraquim P, Pham C, Pu LL, Putman NH, Rabouille C, Ramos OM, Rhodes AC, Robertson HE, Robertson HM, Ronshaugen M, Rozas J, Saada N, Sánchez-Gracia A, Scherer SE, Schurko AM, Siggens KW, Simmons D, Stief A, Stolle E, Telford MJ, Tessmar-Raible K, Thornton R, van der Zee M, von Haeseler A, Williams JM, Willis JH, Wu Y, Zou X, Lawson D, Muzny DM, Worley KC, Gibbs RA, Akam M, Richards S.
PLoS Biol.12(11):e1002005. (PubMed)

HSF-1-mediated cytoskeletal integrity determines thermotolerance and life span
Baird NA, Douglas PM, Simic MS, Grant AR, Moresco JJ, Wolff SC, Yates JR 3rd, Manning G, Dillin A.
Science 346(6207):360-3. (PubMed)

Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer
Liu J, McCleland M, Stawiski EW, Gnad F, Mayba O, Haverty PM, Durinck S, Chen YJ, Klijn C, Jhunjhunwala S, Lawrence M, Liu H, Wan Y, Chopra V, Yaylaoglu MB, Yuan W, Ha C, Gilbert HN, Reeder J, Pau G, Stinson J, Stern HM, Manning G, Wu TD, Neve RM, de Sauvage FJ, Modrusan Z, Seshagiri S, Firestein R, Zhang Z.
Nat Commun 5:3830. (PubMed)

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties
Murphy JM, Zhang Q, Young SN, Reese ML, Bailey FP, Eyers PA, Ungureanu D, Hammaren H, Silvennoinen O, Varghese LN, Chen K, Tripaydonis A, Jura N, Fukuda K, Qin J, Nimchuk Z, Mudgett MB, Elowe S, Gee CL, Liu L, Daly RJ, Manning G, Babon JJ, Lucet IS.
Biochem J 457(2):323-34 (PubMed)

2013

Discovery of a metabolic alternative to the classical mevalonate pathway
Dellas N, Thomas ST, Manning G, Noel JP.
Elife 2:e00672. (PubMed)

Insulin biosynthetic interaction network component, TMEM24, facilitates insulin reserve pool release
Pottekat A, Becker S, Spencer KR, Yates JR 3rd, Manning G, Itkin-Ansari P, Balch WE.
Cell Rep 4(5):921-30. (PubMed)

The Capsaspora genome reveals a complex unicellular prehistory of animals
Suga H, Chen Z, de Mendoza A, Sebé-Pedrós A, Brown MW, Kramer E, Carr M, Kerner P, Vervoort M, Sánchez-Pons N, Torruella G, Derelle R, Manning G, Lang BF, Russ C, Haas BJ, Roger AJ, Nusbaum C, Ruiz-Trillo I.
Nat Commun 4:2325 (PubMed)

Assessment of computational methods for predicting the effects of missense mutations in human cancers
Gnad F, Baucom A, Mukhyala K, Manning G, Zhang Z.
BMC Genomics 14 Suppl 3:S7. (PubMed)

Premetazoan genome evolution and the regulation of cell differentiation in the choanoflagellate Salpingoeca rosetta
Fairclough SR, Chen Z, Kramer E, Zeng Q, Young S, Robertson HM, Begovic E, Richter DJ, Russ C, Westbrook MJ, Manning G, Lang BF, Haas B, Nusbaum C, King N.
Genome Biol 14(2):R15. (PubMed)

Identification of a mammalian-type phosphatidylglycerophosphate phosphatase in the Eubacterium Rhodopirellula baltica
Teh PG, Chen MJ, Engel JL, Worby CA, Manning G, Dixon JE, Zhang J.
J Biol Chem 288(7):5176-85. (PubMed)

2012

Ishikawa, HO, Xu, A, Ogura, E, Manning, G, Irvine, KD. The Raine syndrome protein FAM20C is a Golgi kinase that phosphorylates biomineralization proteins. PLoS One, 7:e42988 (PubMed, PDF).

Vilchez, D, Morrante, I, Liu, Z, Douglas, P, Merkwirth, C, Rodrigues, APC, Manning, G, Dillin, A. RPN-6 determines C. elegans longevity under proteotoxic stress conditions. Nature, in press (PubMed, PDF).

Ngaki, MN, Louie, GV, Manning, G, Pojer, F, Bowman, ME, Larsen, E, Wurtele, ES, Noel, JP. Evolution of the Chalcone Isomerase Fold from Fatty Acid-Binding to Stereospecific Enzyme. Nature, 485:530-3 (PubMed, PDF).

Suga, H, Dacre, M, deMendoza, A, Shalchian-Tabrizi, K, Roger, AJ, Manning, G, Ruiz-Trillo, I. Ancient establishment of cytoplasmic-type and lineage-specific diversification of receptor-type protein tyrosine kinases in opisthokonts: a genomic survey in premetazoan lineages. Science Signaling, 5:ra35 (PubMed, PDF).

2011

Mair, W, Morantte, I, Rodrigues, AP, Manning, G, Montminy, M, Shaw, RJ, Dillin, A. Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB. Nature 470:404-8. (PubMed, PDF).

Interntational Selaginella Genome Sequencing Consortium. The Selaginella Genome Identifies Genetic Changes Associated with the Evolution of Vascular Plants. Science 332:960-3 (PubMed, PDF).

de Cárcer G, Escobar B, Higuero A, Garcia L, Anson A, Pérez G, Mollejo M, Manning G, Meléndez B, Abad Rodriguez J, Malumbres M. Plk5, a Polo-box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression. Mol Cell Biol 31:1225-39 (PubMed, PDF).

Manning, G, Reiner, DS, Lauwaet, T, Dacre, M, Smith, A, Zhai, Y, Svard, S, Gillin, FD. The Minimal Kinome of Giardia lamblia Illuminates Early Kinase Evolution and Unique Parasite Biology. Genome Biology, 12:R66. (PubMed, PDF).

Baranov, PV, Wills, NM, Barriscale, KA, Firth, AE, Jud, MC, Letsou, A, Manning, G, Atkins, JF. Programmed ribosomal frameshifting in the expression of the regulator of intestinal stem cell proliferation, adenomatous polyposis coli (APC). RNA Biology, 8:1-11 (PubMed, PDF).

de Cárcer, G, Manning, G, Malumbres, M. From Plk1 to Plk5: functional evolution of Polo-like kinases. Cell Cycle, 10(14) 2255-62 (PubMed, PDF).

Xiao, J, Engel, JL, Zhang, Ji, Chen, MJ, Manning, G, Dixon, JE. Molecular insights into substrate recognition and activation of PTPMT1, the mammalian phosphatidylglycerol phosphate phosphatase. PNAS, 108:11860-5 (PubMed, PDF).

Mattoo, S, Durrant, E, Chen, MJ, Xiao, J, Manning, G, Dixon, JE, Worby, CA. Comparative analysis of Histophilus somni IbpA with other Fic enzymes reveals differences in substrate and nucleotide specificities. J. Biol. Chem., in press (PubMed, PDF).

2010

Scheeff, ED, Axelrod, HL, Miller, MD, Chiu, H-J, Deacon, AM, Wilson, IA, Manning, G. Genomics, Evolution, and Crystal Structure of a New Family of Bacterial Spore Kinases. Proteins 78:1470-82 (PubMed, PDF, Research Highlight).

Walker, CB, de la Torre, JR, Arp, D, Bruce, DA, Chain, P, Hugler, M, Karr, E, Klotz, MG, Konneke, M, Pinel, N, Sayavedra-Soto, L, S. Sievert, S, Richardson, PM, Golabgir-Anbarani, A, Manning, G, Stahl, DA. The genome of Nitrosopumilus maritimus SCM1, a representative of the globally distributed marine crenarchaea. PNAS 107:8818-23 (PubMed, PDF).

Stajich, JE, Wilke, SK, Ahrén, D, Au, TCH, Birren, BW, Borodovsky, M, Burns, C, Canback, B, Casselton, LA, Cheng, BCK, Deng, J, Dietrich, FS, Fargo, DC, Farman, M, Gathman, AC, Goldberg, J, Guigo, R, Hoegger, P, Hooker, JB, Huggins, A, James, TY, Kamada, T, Kilaru, S, Kodira, C, Kues, U, Kwan, H-S, Li, W, Lilly, WL, Ma, L-J, Mackey, AJ, Manning, G, Martin, F, Muraguchi, H, Palmerini, H, Ramesh, M, Rehmeyer, C, Shenoy, N, Stanke, M, Tunlid, A, Velagapudi, R, Vision, TJ, Zeng, Q, Zolan, ME, Pukkila, PJ. Genome evolution in mushrooms: insights from the assembled chromosomes of the basidiomycete Coprinopsis cinerea (Coprinus cinereus) PNAS 107:11889-94 (PubMed, PDF).

Srivastava, M, Simakov, O, Chapman, J, Mitros, T, Hellsten, U, Putnam, NH, Fahey, B, Gauthier, M, Larroux, C, Richards, G, Stanke, M, Adamska, M, Darling, A, Dacre, M, Degnan, S, Zhai, Y, Adamski, M, Calcino, A, Goodstein, DM, Shengqiang Shu, S, Woodcroft, B, Martindale, M, Leys, S, Manning, G, Degnan, B, Rokhsar, DS. The genome of the haplosclerid demosponge Amphimedon queenslandica and the evolution of animal complexity. Nature, 466:720-726 (PubMed, PDF).

Manning G, Scheeff E. How the vertebrates were made: selective pruning of a double-duplicated genome. BMC Biology, 8:144 (PubMed, PDF).

2009

Scheeff, ED, Eswaran, J, Bunkoczi, G, Knapp, S, Manning, G. Structure of the pseudokinase VRK3 reveals a degraded catalytic site, a highly conserved kinase fold, and a putative regulatory binding site. Structure 17:128-38 (PubMed , PDF, Perspective, Website).

Copp, J, Manning, G, Hunter, T. TORC specific phosphorylation of mTOR: phospho-Ser2481 is a marker for intact mTORC2. Cancer Research 69:1821-7 (PubMed, PDF).

Bomati, EK, Manning, G, Deheyn, DD. Amphioxus encodes the largest known family of green fluorescent proteins, which have diversified into distinct functional classes. BMC Evol. Biol. 9: 77 (PubMed, PDF).

Scheeff, ED and Fink, JL. Fundamentals of Protein Structure. In Structural Bioinformatics, 2nd ed. (ed. Gu, J and Bourne PE) Wiley-Blackwell, Ch 2:15-40 (Website).

Manning, G, Hunter, T. Eukaryotic Kinomes: Genomics and Evolution of Protein Kinases. In Handbook of Cell Signaling, 2nd ed. (ed. Bradshaw, RA and Dennis, E). Academic Press, San Diego (Amazon).

Zhang, Y-W, Brognard, J, Coughlin, C, You, Z, Dolled-Filhart, M, Aslanian, A, Manning, G, Abraham, RT, Hunter, T. The F Box Protein Fbx6 Regulates Chk1 Stability and Cellular Sensitivity to Replication Stress. Molecular Cell, 35:442-453 (PubMed, PDF).

Malumbres, M, Harlow, E, Hunt, T, Hunter, T, Lahti, JM, Manning, G, Morgan, DO, Tsai, L-H, Wolgemuth, DJ. Cyclin-dependent kinases: a family portrait. Nature Cell Biology, 11:1275-6 (PubMed, PDF).

Nathanson, JL, Jappelli, R, Scheeff, E, Manning, G, Yanagawa, Y, Obata, K, Brenner, S, Callaway, EM. Short Promoters in Viral Vectors Drive Selective Expression in Mammalian Inhibitory Neurons, but Do Not Restrict Activity to Specific Inhibitory Cell-Types. Frontiers in Neural Circuits, 3:19 (PubMed, PDF).

Hutt, DM, Herman, D, Rodrigues, APC, Noel, S, Pilewski, J, Matteson, J, Kellner, W, Kelly, JW, de Jonge, HR, Riordan, JR, Sorscher, E, Frizzell, RA, Manning, G, Gottesfeld, JM, Balch, WE. Epigenomic Correction of Cystic Fibrosis through HDAC Modification. Nature Chemical Biology, 6:25-33 (PubMed, PDF).

2008

King, N, Westbrook, MJ, Young, SL, Kuo, A, Abedin, M, Chapman, J, Fairclough, S, Hellsten, U, Isogai, Y, Letunic, I, Marr, M, Pincus, D, Putman, N, Rokas, A, Wright, KJ, Zuzow, R, Dirks, W, Good, M, Goodstein, D, Lemons, D, Li, W, Lyos, J, Morris, A, Nichols, S, Richter, DJ, Salamov, A, JGI Sequencing, Bork, P, Lim, WA, Manning, G, Miller, WT, McGinnis, W, Shapiro, H, Tijan, R, Grigoriev, IV, Rokhsar, D. The genome of the choanoflagellate Monosiga brevicollis and the origins of metazoan multicellularity. Nature 451, 783-788 (PubMed , PDF)

Manning, G, Young, SL, Miller, WT, Zhai, Y. The protist, Monosiga brevicollis, has a tyrosine kinase signaling network more elaborate and diverse than found in any known metazoan. PNAS, 105: 9674-79 (PDF, PubMed, website).
Science's Editor's Choice, and a 2008 Signaling Breakthrough of the Year by Science Signaling.

Vilar, M, Chou, H-T, Luhrs, T, Maji, S, Riek-Loher, D, Verel, R, Manning, G, Stahlberg, H, Riek, R. The Fold of α-Synuclein Fibrils. PNAS 105:8637-42 (PubMed, PDF).

O'Maille, PE, Malone, A, Dellas, N, Hess, A, Sheehan, I, Greenhagen, B, Chappell, J, Manning, G, Noel, JP. Phylogenetically and structurally defined sequence space connecting divergent plant sesquiterpene synthases. Nature Chemical Biology, 4:617-23 (PubMed, PDF).

2007

Natarajan, K, Taylor, S, Zhai, Y, Venter, C, Manning, G. Structure and function of the microbial kinome. PLoS Biol. 5(3):e17. (PubMed , PDF)

Yooseph, S., G. Sutton, D.B. Rusch, S. Williamson, A.L. Halpern, K. Remington, J.A. Eisen, K. Heidelberg, G. Manning, W. Li, L. Jaroszewski, P. Cieplak, C. Miller, H. Li, S.T. Mashiyama, M. Joachimiak, C.v. Belle, J.-M. Chandonia, D. Soergel, Y. Zhai, K. Natarajan, S. Lee, B.J. Raphael, V. Bafna, R. Friedman, S.E. Brenner, A. Godzik, D. Eisenberg, J. Dixon, S. Taylor, M. Frazier, R. Strausberg and J.C. Venter. The Sorcerer II Global Ocean Sampling Expedition: Expanding the Universe of Protein Families. PLoS Biol. 5(3):e16 (PubMed , PDF)

Morrison, HG, McArthur, AG, Gillin, FD, Aley, SB, Adam, RD, Olsen, GJ, Reiner, DS, Svard, SG, Elmendorf, HG, Hehl, AB, Samuelson, J, Nixon, JEJ, Passamaneck, NE, Kim, UU, Lasek-Nesselquist, E, Cipriano, MJ, Holder, ME, Huse, SM, Palm, D, Best, AA, Reich, CI, Manning, G, Nigam, A, Prabu, A, Davids, BS, Sogin, ML. Genomic minimalism in the early diverging intestinal parasite, Giardia lamblia. Science 317(5846):1921-6 (PubMed, PDF)

Chung JL, Beaver JE, Scheeff ED, Bourne PE. Con-Struct Map: a comparative contact map analysis tool. Bioinformatics 23:2491-2. (PubMed, PDF)

Perrin. MH, Grace. CR, Digruccio. MR, Fischer. WH, Maji. SK, Cantle. JP, Smith S, Manning. G, Vale. WW, Riek. R. Distinct structural and functional roles of conserved residues in the first extracellular domain of receptors for corticotropin releasing factor and related G-protein coupled receptors. J. Biol. Chem. 282(52): 37529-36 (PubMed, PDF)

Slabinski, L, Jaroszewski, L, Rodrigues, APC, Rychlewski, L, Wilson, IA, Lesley, SA, Godzik, A. The challenges of protein structure determination - lessons from structural genomics. Protein Science 16:2472-82 (PubMed, PDF)

2006

Sea Urchin Genome Sequencing Consortium. The genome of the sea urchin Strongylocentrotus purpuratus. Science 314:941-52. (PubMed , PDF)

Bradham, CA, Foltz, KR, Beane, WS, Arnone, MI, Rizzo, F, Coffman, JA, Mushegian, A, Goel, M, Morales, J, Geneviere, A, Lapraz, F, Robertson, AK, Kelkar, H, Loza-Coll, M, Townley, IK, Raisch, M, Rouz, MM, Legpage, T, Gache, C, McClay, DR, Manning, G. The Sea Urchin Kinome: A First Look. Dev. Biol. 300:180-93. (PubMed , PDF)

Scheeff, ED, Bourne, PE. Application of protein structure alignments to iterated hidden Markov model protocols for structure prediction. BMC Bioinformatics 7:410 (PubMed , PDF)

Eisen JA, Coyne RS, Wu M, Wu D, Thiagarajan M, Wortman JR, Badger JH, Ren Q, Amedeo P, Jones KM, Tallon LJ, Delcher AL, Salzberg SL, Silva JC, Haas BJ, Majoros WH, Farzad M, Carlton JM, Smith RK, Garg J, Pearlman RE, Karrer KM, Sun L, Manning G, Elde NC, Turkewitz AP, Asai DJ, Wilkes DE, Wang Y, Cai H, Collins K, Stewart BA, Lee SR, Wilamowska K, Weinberg Z, Ruzzo WL, Wloga D, Gaertig J, Frankel J, Tsao CC, Gorovsky MA, Keeling PJ, Waller RF, Patron NJ, Cherry JM, Stover NA, Krieger CJ, Del Toro C, Ryder HF, Williamson SC, Barbeau RA, Hamilton EP, Orias E. Shotgun sequencing and analysis of the macronuclear genome of the model eukaryote, the ciliate Tetrahymena thermophila. PLoS Biol. 4 (9): e286. (PubMed , PDF)

Schröfelbauer, B, Senger, T, Manning, G, Landau, NR. Alteration of HIV-1 Vif allows functional interaction with primate APOBEC3G. J. Virol. 80 (12), 5984-91. (PubMed , PDF)

Wloga, D, Camba, A, Rogowski, K, Manning, G, Dziadosz, M, Gaertig, J. Members of the Nima-related Kinase family Promote Disassembly of Cilia by Multiple Mechanisms. Molec. Biol. Cell, 17(6): 2799-810. (PubMed , PDF)

Goldberg, JM, Manning, G, Liu, A, Fey, P, Pilcher, KE, Xu, Y, Smith, JL. The Dictyostelium Kinome - Analysis of the Protein Kinases from a Simple Model Organism. PLoS Genet. 2 (3): e38 (PubMed , PDF)

2005

Manning, G. Genomic overview of Protein Kinases (December 13, 2005), WormBook, ed. The C. elegans Research Community, WormBook, doi/10.1895/wormbook.1.60.1, (HTML, PDF)

2004

Caenepeel, S, Charydczak, G, Sudarsanam, S. Hunter, T., Manning, G. The Mouse Kinome: Discovery and comparative genomics of all mouse protein kinases. PNAS 101 (32), 11707-12(PubMed , PDF)